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· DOS Abstracts
Autologous Dual Tissue Transplantation for
Osteochondral repair - One Year Clinical and
Radiological Follow-Up
Bjørn Christensen, Casper Foldager, Martin Lind
Orthopedic Research Laboratory, Aarhus University Hospital; Division of Sports
trauma, Aarhus University Hospital
Background:
Articular cartilage has a very limited potential for spontaneous
regeneration, due to the avascular nature of the tissue. Numerous treatment
methods have been implemented, among them microfracture, ACI and mosaic-
plasty, but no Gold standard treatment has been established.
Purpose / Aim of Study:
To evaluate the use of Autologous Dual- Tissue
Transplantation (ADTT): An easily applicable, low cost treatment option for ar-
ticular cartilage repair.
Materials and Methods:
Eight patients (age 33 years, range: 24-45) suffer-
ing from osteochondral defects of the medial femoral condyle were enrolled.
The injury area was debrided and the osteochondral defect was filled with au-
tologous bone from the tibial tuberosity, to the level of the adjacent cartilage.
Cartilage biopsies from the intercondylar notch, was chipped, and the cartilage
chips were embedded in fibrin glue in the defect. The stability of the treatment
was tested with 40 full range motions, and the incision was closed. The patients
were evaluated pre- operatively and one year post-operatively using MRI, CT,
and clinical scores (KOOS, IKDC and Tegner)
Findings / Results:
A significant improvement was found in the IKDC score
(from 40,2 – 67,5, p=0,02), the Tegner score (2,8 – 4,6, p=0,01) and KOOS
pain, symptoms, sport/rec and quality of life. The MOCART MRI score improved
from 30 to 62,5 (p=0,0003). CT imaging showed very good defect filling, with
an uneven bone surface.
Conclusions:
Treatment of osteochondral injuries in the knee with ADTT result-
ed in significant clinical and radiological improvements at one year. Despite the
limited number of patients and the short-term follow-up, this study highlights
ADTT as a promising treatment option for osteochondral injuries.
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