DOS Kongressen 2014 ·
67
Limited Osteochondral Repair by a Biomimetic
Collagen Scaffold - One to Three Years Clinical and
Radiological Follow-Up
Bjørn Christensen, Casper Foldager, Niels Christian Jensen, Cody Bünger,
Martin Lind
Orthopedic Research Laboratory, Aarhus University Hospital; Department of
Orthopedic Surgery, Aarhus University Hospital; Division of Sports trauma,
Aarhus University Hospital
Background:
Osteochondral injuries are therapeutically challenging and no gold
standard treatment has been established. Cell-free, layered scaffolds are a new
treatment option for these defects.
Purpose / Aim of Study:
The aim of this study was to evaluate the osteo-
chondral repair in patients treated with The MaioRegen® scaffold, a cell-free
biomimetic scaffold. It has previously been shown to induce clinical subchondral
bone and articular cartilage regeneration.
Materials and Methods:
Eleven patients with osteochondral defects in the
knee (n=7) or in the talus (n=4) were enrolled. Patients filled out clinical evalu-
ation questionnaires pre-OP and at the final follow-up (2,5 years, range 1,9-
3,1 years). The patients underwent pre-OP MRI, and CT and MRI 1 (range
1-1,2 years) and 2,5 years post-OP (range 1,9-3,1 years). The knee patients
were evaluated using KOOS, IKDC and Tegner, the ankle patients using AOFAS
Hindfoot and Tegners score. The cartilage and bone formation was evaluated
using the MOCART score.
Findings / Results:
Three patients were re-operated and excluded due to
treatment failure. CT: None of the patients had complete regeneration of the
bone. 6/8 patients had no or very limited (<10%) bone formation. 1/8 had 20-
30% bone filling and 1/8 had 40-50% bone filling. MRI: No improvement was
found in the MOCART score at any time point. 5/6 patients experienced a clini-
cal improvement, and one patient a worsening. The results were insignificant.
Conclusions:
Treatment of osteochondral defects with the MaioRegen scaffold
resulted in incomplete cartilage- and limited subchondral bone repair at 1 and
2,5 year’s follow-up. Three patients were excluded due to treatment failure. This
study raises concerns about the biological repair potential of the MaioRegen®
implant. Long-term studies are needed to investigate if the clinical improve-
ments are permanent.
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