64.
Survival Analysis Of The Breast Cancer Subtypes With Spinal
Metastases
Miao Wang, Jensen Anders, Ming Sun, Søren Morgen, Benny Dahl, Cody
Bünger
Department of Orthopaedic E Aarhus University Hospital NBG; Department
of Oncology, Aarhus University Hospital; Department of Orthopaedic E,
Aarhus University Hospital NBG; Spine Unit, Rigshospitalet Copenhagen;
Spine Unit, Rigshospitalet Copenhagen; Department of Orthopaedic E, Aarhus
University Hospital NBG
Background:
Preoperative prognosis of the spinal metastases patients is a
challenge for the spine surgeon to choose optimal treatments. Now the popular
scoring systems (such as Tokuhashi score) are only focusing on the primary
site. Breast cancer is one of the most common tumors that involve the spine.
The subtypes could significantly influence the survival period of the breast
cancer patients. Estrogen receptor (ER) and Progestogen receptor (PR) status
are the key factors of the subtypes.
Purpose / Aim of Study:
The aim was to investigate the influence of breast
cancer subtypes for the survival of the breast cancer spinal metastases patients
Materials and Methods:
Eighty-four patients with breast cancer spinal
metastases underwent surgical treatments since 1997 to 2011 were analyzed.
The ER and PR status data were retrieved from the Danish Breast Cancer
Group. We used survival analysis, created the Kaplan-Meier curves and run
Log-rank test to compare the survival outcomes. The P value less than 0.05
was consider significant.
Findings / Results:
In the ER subtypes, 72 patients were positive, 12 patients
were negative. Fifty-two patients were dead, and 32 patients were alive. The
result from the Log-rank test showed that the difference of survival rates
between the ER+ and ER- was not significant (p=0.44). Forty-seven patients
had PR results. In the PR subtypes, 28 patients were positive, 19 patients were
negative. Twenty-three patients were dead, and 24 patients were alive. The
mortality rates had no significant difference (p=0.22) between PR+ and PR-
subtypes.
Conclusions:
The mortality rate between each subtype did not show any
significant differences. The subtypes of the breast cancer do not influence the
prognosis of the spinal metastases patients. Spine surgeons do not need to
distinguish the breast cancer subtypes to predict the spinal metastases.
