DOS 2020

82 · DOS Abstracts Physical function is reduced and correlated to quality of life after limb-sparing surgery due to bone sarcoma Linda Fernandes, Kreutzfeldt Zebis Mette, Michala Skovlund Sørensen , Christina Enciso Holm , Allan Villadsen , Michael Mørk Peteresen Musculoskeletal Tumour Section, Department of Orthopaedic Surgery, Rigshospitalet and University College Copenhagen ; Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen; Musculoskeletal Tumour Section, Department of Orthopaedic Surgery, Rigshospitalet Background: Patients with bone sarcoma report that quality of life (QoL) is affected years after treatment. In rehabilitation, both QoL and different mea- sures of physical function are assessed and targeted. However, few studies have investigated physical function and its relationship to QoL in this patient group. Purpose / Aim of Study: The purpose was to investigate if physical function in patients with bone sarcoma receiving limb-sparing surgery (LSS) and recon- struction with a tumour- prosthesis was affected and associated with QoL. Materials and Methods: Thirty patients operated (proximal femur (n=12), distal femur (n=14), proximal tibia (n=4)) between 2006 and 2016 were com- pared to 30 healthy controls in a cross-sectional design. Differences between groups were tested for objectively measured physical function: isometric muscle strength in gluteus medius and quadriceps, six-minute walk test (6MWT) and 30s sit-to-stand test (STS). In the patient group, measures of physical function were correlated with EORTC QLQ-C30 Global Health (GH), Physical functioning (PF) and Role functioning (RF) subscales. Paired samples t-test was used for analyses of between group differences and Spearman’s rank correlation for as- sociations within the patient group. Findings / Results: Mean age of participants was 51 years and mean BMI 26. Significant (statistical and clinical) differences were found for all muscle strength tests between the two groups, both for comparisons of the leg that under- went surgery and the contralateral leg. Significant differences were also seen for the 6MWT (499 vs. 607 m, p<0.001) and the STS (12 vs. 18, p<0.001). Physical function was correlated to QoL when comparing muscle strength of gluteus medius with GH (rho 0.43, p=0.019) and with PF (rho 0.51, p=0.006), and quadriceps strength with PF (rho 0.40, p=0.034) and with RF (rho 0.40, p=0.038). Conclusions: Patients with bone sarcoma receiving LSS and reconstruction with a tumour-prosthesis showed deficits in muscle strength, 6MWT and STS when compared to controls. Decreased strength of gluteus medius and quadri- ceps muscles correlated to QoL subscales, indicating that strength training could be a potential factor for improving physical components of QoL. 69.